Low-cost, point-of-care tests for HIV and malaria have completely transformed the management of these serious diseases. By contrast, suboptimum and delayed diagnosis of tuberculosis continues to fuel the epidemic in many high-burden countries, especially those with a high prevalence of HIV infection. The need for a instrument-free and laboratory-free, point-of-care test for tuberculosis cannot be overstated. Although the pipeline for tuberculosis diagnostics is substantially healthier than it was even 5 years ago, absence of a dipstick-type point-of-care test continues to be a gaping hole in the pipeline.
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