Clonal hypereosinophilic syndrome: two cases report in black men from sub-saharan Africa and literature reviews.
ISRN Hematol. 2011;2011:974609
Authors: Messie K, Vovor A, Kueviakoe IM, Sallah LK, Agbetiafa K, Segbena AY
Abstract
The first case is about a man of 60 years old suffering of hypereosinophilic syndrome (HES) developed since 1998. He presented chronic cough, insomnia, and negative parasitical test. We observed hypereosinophilia and fibroblastic hyperplasia at the bone marrow biopsy. Initially, hydroxyurea and α-interferon treatment failed. We proposed to him imatinib mesylate in May 2003. The FIP1L1-PDGFRA gene was detected. The second case is about a man of 34 years old seen in March 2002. First investigation concluded to CML. Progressively, eosinophil cells increased, and complications occurred as oedema syndrome, dyspnoea, and parietal chronic endocarditic fibrosis associated with pericarditis. In addition, a bowel obstruction happened and was cured by surgery. Bcr-abl fusion was negative, and FIP1L1-PDGFRA gene was detected after and imatinib mesylate was given. Actually, endocarditic fibrosis decreased. The two patients are in haematological and cytogenetic remission. We concluded that clonal HES is present in Africa, and imatinib mesylate is effective.
PMID: 22135755 [PubMed - in process]
References
- Messie K, Vovor A, Kueviakoe IM, Sallah LK, Agbetiafa K, Segbena AY. Clonal hypereosinophilic syndrome: two cases report in black men from sub-saharan Africa and literature reviews. ISRN Hematol. 2011;2011:974609. PMID: 22135755.
Related posts:
- [Stevens-Johnson syndrome and toxic epidermal necrolysis in a teaching hospital in Lomé, Togo: retrospective study of 89 cases]
- Cost-effectiveness of laboratory monitoring in sub-Saharan Africa: a review of the current literature.
- Best practices for an insecticide-treated bed net distribution programme in sub-Saharan eastern Africa.
- Data availability on men’s involvement in families in sub-Saharan Africa to inform family-centred programmes for children affected by HIV and AIDS.
- The challenge of diagnosing Plasmodium ovale malaria in travellers: report of six clustered cases in French soldiers returning from West Africa
