Objective: To describe lipid levels in antiretroviral (ARV)-naïve HIV-infected Ivorian children and assess their evolution after ARV-treatment initiation. Methods: Lipid concentrations were assessed at baseline and at least 6 months later in 93 children. Fifty-six children initiated ARV treatment at baseline, and 37 remained untreated. Results: At baseline, 65, 92 and 84% of the children had low levels of total cholesterol, HDL and APOA1, respectively, whereas 75 and 70% had triglycerides and APOB levels in the normal range. At baseline, low level of HDL cholesterol and high level of triglycerides were associated with high viral load and low levels of CD4 cell count. Levels of total, HDL cholesterol and APOA1 increased over time, and treatment was associated with a higher increase whereas levels of triglycerides and APOB decreased in treated children and remained stable in untreated group. Conclusions: The initiation of antiretroviral treatment was associated with a normalization of the infection-related lipid profile.
Related posts:
- Lipid Profiles in Young HIV-infected Children Initiating and Changing Antiretroviral Therapy.
- Severe morbidity and mortality in untreated HIV-infected children in a paediatric care programme in Abidjan, Cote d’Ivoire, 2004-2009
- Prevalence of Helicobacter pylori in HIV-infected, HAART-naive Ugandan children: a hospital-based survey
- Metabolic and anthropometric parameters contribute to ART-mediated CD4+ T cell recovery in HIV-1-infected individuals: an observational study.
- Assessment of the prevalence of distal symmetrical polyneuropathy and its risk factors among HAART-treated and untreated HIV infected individuals.
