Researchers at the Johns Hopkins Bloomberg School of Public Health have, for the first time, shown that infection with dengue virus turns on mosquito genes that makes them hungrier and better feeders, and therefore possibly more likely to spread the disease to humans. Specifically, they found that dengue virus infection of the mosquito’s salivary gland triggered a response that involved genes of the insect’s immune system, feeding behavior and the mosquito’s ability to sense odors. The researchers findings are published in the March 29 edition of PLoS Pathogens. Read More
Researchers identify genetic basis of tropical foot and leg lymphedema
Wearing shoes and genomics are tied together in strategy to eliminate podoconiosis
Farmers in the highlands of southern Ethiopia scratch out a subsistence living from the region’s volcanic red clay. The soil supports the farms, but fine-grained, volcanic rock particles in the dirt threaten the farmers and their families. Continual exposure of bare feet to the volcanic soil causes 1 in 20 people to develop a painful inflammation of the lower extremities that, over time, leads to foot disfigurement. Doctors call it podoconiosis. The locals call it mossy foot. And those affected suffer social stigma as well as debilitating discomfort. Read More
Analysing Spatio-Temporal Clustering of Meningococcal Meningitis Outbreaks in Niger Reveals Opportunities for Improved Disease Control
by Juliette Paireau, Florian Girond, Jean-Marc Collard, Halima B. Maïnassara, Jean-François Jusot
Background
Meningococcal meningitis is a major health problem in the “African Meningitis Belt” where recurrent epidemics occur during the hot, dry season. In Niger, a central country belonging to the Meningitis Belt, reported meningitis cases varied between 1,000 and 13,000 from 2003 to 2009, with a case-fatality rate of 5–15%. Read More
Addressing the Neglected Tropical Disease Podoconiosis in Northern Ethiopia: Lessons Learned from a New Community Podoconiosis Program
by Sara Tomczyk, Abreham Tamiru, Gail Davey
Background
Despite its great public health importance, few control initiatives addressing podoconiosis (non-filarial elephantiasis, a geochemical neglected tropical disease) exist. In June 2010, the first podoconiosis program in Northern Ethiopia, consisting of prevention, awareness, and care and support activities, began in Debre Markos, Northern Ethiopia. Read More
Implementing Preventive Chemotherapy through an Integrated National Neglected Tropical Disease Control Program in Mali
by Massitan Dembélé, Sanoussi Bamani, Robert Dembélé, Mamadou O. Traoré, Seydou Goita, Mamadou Namory Traoré, Abdoul Karim Sidibe, Letitia Sam, Marjon Tuinsma, Emily Toubali, Chad MacArthur, Shawn K. Baker, Yaobi Zhang
Background
Mali is endemic for all five targeted major neglected tropical diseases (NTDs). As one of the five ‘fast-track’ countries supported with the United States Agency for International Development (USAID) funds, Mali started to integrate the activities of existing disease-specific national control programs on these diseases in 2007. Read More
Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis
by Sebastian Ziewer, Marc P. Hübner, Bettina Dubben, Wolfgang H. Hoffmann, Odile Bain, Coralie Martin, Achim Hoerauf, Sabine Specht
Background
Lymphatic filariasis and onchocerciasis are two chronic diseases mediated by parasitic filarial worms causing long term disability and massive socioeconomic problems. Filariae are transmitted by blood-feeding mosquitoes that take up the first stage larvae from an infected host and deliver it after maturation into infective stage to a new host. Read More
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Lymphatic Filariasis (Tropical Medicine - Science and Practice , Vol 1) :: Amazon From a series dedicated to the understanding of tropical diseases, this volume examines the basic biology and clinical expression of lymphat |
Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
Scientists at A*STAR’s Singapore Immunology Network have made great strides in the battle against the infectious disease
Recent breakthroughs in Chikungunya research spearheaded by scientists at A*STAR’s Singapore Immunology Network (SIgN) have made great strides in the battle against the infectious disease. Working in close collaborations with Singapore clinician-scientists and international researchers , Dr Lisa Ng, Principal Investigator of the Chikungunya research group at SIgN, led the team to discover a direct biomarker which serves as an early and accurate prognosis of patients who have a higher risk of the more severe form of Chikungunya fever (CHIKF). Read More
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New and Emerging Infectious Diseases, An Issue of Medical Clinics, 1e (The Clinics: Internal Medicine) :: Amazon As expanding human communities result in radical modifications to our natural environments, previously harmless micro-organisms take on leth |
The Burden of Trachoma in South Sudan: Assessing the Health Losses from a Condition of Graded Severity
by Hebe Gouda, John Powles, Jan Barendregt, Paul Emerson, Jeremiah Ngondi
Introduction
Trachoma is a disease that can lead to visual impairment and ultimately blindness. Previous estimates of health losses from trachoma using the Global Burden of Disease methodology have not, however, included the stage prior to visual impairment. We estimated the burden of all stages of trachoma in South Sudan and assessed the uncertainty associated with the severity and duration of stages of trachoma prior to full blindness. Read More
Distribution and Molecular Evolution of Bacillus anthracis Genotypes in Namibia
by Wolfgang Beyer, Steve Bellan, Gisela Eberle, Holly H. Ganz, Wayne M. Getz, Renate Haumacher, Karen A. Hilss, Werner Kilian, Judith Lazak, Wendy C. Turner, Peter C. B. Turnbull
The recent development of genetic markers for Bacillus anthracis has made it possible to monitor the spread and distribution of this pathogen during and between anthrax outbreaks. In Namibia, anthrax outbreaks occur annually in the Etosha National Park (ENP) and on private game and livestock farms. We genotyped 384 B. anthracis isolates collected between 1983–2010 to identify the possible epidemiological correlations of anthrax outbreaks within and outside the ENP and to analyze genetic relationships between isolates from domestic and wild animals. Read More
Mapping of Schistosomiasis and Soil-Transmitted Helminthiasis in the Regions of Centre, East and West Cameroon
by Louis-Albert Tchuem Tchuenté, Romuald Isaka Kamwa Ngassam, Laurentine Sumo, Pierre Ngassam, Calvine Dongmo Noumedem, Deguy D’or Luogbou Nzu, Esther Dankoni, Christian Mérimé Kenfack, Nestor Feussom Gipwe, Julie Akame, Ann Tarini, Yaobi Zhang, Fru Fobuzski Angwafo
Background
Schistosomiasis and soil-transmitted helminthiasis (STH) are widely distributed in Cameroon. Although mass drug administration (MDA) of mebendazole is implemented nationwide, treatment with praziquantel was so far limited to the three northern regions and few health districts in the southern part of Cameroon, based on previous mapping conducted 25 years ago. To update the disease distribution map and determine where treatment with praziquantel should be extended, mapping surveys were conducted in three of the seven southern regions of Cameroon, i.e. Centre, East and West. Read More
Real-time PCR Demonstrates Ancylostoma duodenale Is a Key Factor in the Etiology of Severe Anemia and Iron Deficiency in Malawian Pre-school Children
by Femkje A. M. Jonker, Job C. J. Calis, Kamija Phiri, Eric A. T. Brienen, Harriet Khoffi, Bernard J. Brabin, Jaco J. Verweij, Michael Boele van Hensbroek, Lisette van Lieshout
Background
Hookworm infections are an important cause of (severe) anemia and iron deficiency in children in the tropics. Type of hookworm species (Ancylostoma duodenale or Necator americanus) and infection load are considered associated with disease burden, although these parameters are rarely assessed due to limitations of currently used diagnostic methods. Using multiplex real-time PCR, we evaluated hookworm species-specific prevalence, infection load and their contribution towards severe anemia and iron deficiency in pre-school children in Malawi. Read More
Bacterial Diversity in Oral Samples of Children in Niger with Acute Noma, Acute Necrotizing Gingivitis, and Healthy Controls
by Ignacio Bolivar, Katrine Whiteson, Benoît Stadelmann, Denise Baratti-Mayer, Yann Gizard, Andrea Mombelli, Didier Pittet, Jacques Schrenzel, The Geneva Study Group on Noma (GESNOMA)
Background
Noma is a gangrenous disease that leads to severe disfigurement of the face with high morbidity and mortality, but its etiology remains unknown. Young children in developing countries are almost exclusively affected. The purpose of the study was to record and compare bacterial diversity in oral samples from children with or without acute noma or acute necrotizing gingivitis from a defined geographical region in Niger by culture-independent molecular methods. Read More
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Dental Diseases Differential Diagnosis :: Amazon This is a fully illustrated book which is designed to help students and practitioners to identify two similar looking diseases at ease and e |
Disease Outbreaks- Avian influenza – situation in Indonesia – updateThe Indonesian IHR National Focal Point of the Ministry of Health has notified WHO of a new case of human infection with avian influenza A(H5N1) virus. […]
- Avian influenza – situation in Egypt – updateThe Ministry of Health and Population of Egypt has notified WHO of a new case of human infection with avian influenza A (H5N1) virus. […]
- Avian influenza – situation in Cambodia – updateThe Ministry of Health (MoH) of the Kingdom of Cambodia has announced a confirmed case of human infection with avian influenza A (H5N1) virus. […]
- Lassa fever in NigeriaAt the beginning of 2012, WHO was notified by the Federal Ministry of Health in Nigeria of an outbreak of Lassa fever. As of March 22, 2012, 623 suspected cases, including 70 deaths have been recorded from 19 of the 36 States since the beginning of the year. Laboratory analysis undertaken at the Irrua Specialist Teaching Hospital, Irrua Edo State has confirm […]
- Avian influenza – situation in Egypt – updateThe Ministry of Health and Population of Egypt has notified WHO of two new cases of human infection with avian influenza A (H5N1) virus. […]
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Cheap Calls to Kenya
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Mendeley Related Research
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ReadersNecrotizing gingivitisArray (1966)1
ReadersTherapy of acute ulcerative gingivitisArray (1970)1
ReadersTreatment of necrotizing ulcerous gingivitisArray (1968)1
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