COLUMBUS, Ohio — The bacterium that causes tuberculosis has a unique molecule on its outer cell surface that blocks a key part of the body’s defense. New research suggests this represents a novel mechanism in the microbe’s evolving efforts to remain hidden from the human immune system. Read More
Blood tests for active TB not accurate or cost-effective
Based on data, WHO advises against use of blood antibody test for active TB
Commercial blood serum antibody tests—widely used in India and other developing countries to diagnose active tuberculosis—are not accurate or cost-effective, according to an analysis by researchers at the Johns Hopkins Bloomberg School of Public Health, the University of Washington School of Public Health and McGill University. Read More
New TB vaccine enters proof-of-concept trial in people living with HIV
Vaccine candidate is the most clinically advanced of a new generation of vaccines under development to combat TB and the TB/HIV co-epidemic
ROCKVILLE, MD, USA/LONDON, UK, August 11, 2011 – Aeras and the Oxford-Emergent Tuberculosis Consortium (OETC) announce today the start of a Phase IIb proof-of-concept efficacy trial of a new investigational tuberculosis (TB) vaccine that involves people living with the human immunodeficiency virus (HIV). The trial will be conducted at research sites in Senegal and South Africa with primary funding support from the European and Developing Countries Clinical Trials Partnership (EDCTP). Read More
New discovery brings customized tuberculosis therapies based on genotype closer to reality
New research published in the Journal of Leukocyte Biology suggests that lack of expression of innate immune system receptor may play a critical role in the immune response to mycobacterial infections
Bethesda, MD—Are you genetically predisposed to tuberculosis? Scientists may now be able to answer this question and doctors may be able to adjust their therapeutic approach based on what they learn. That’s because new research presented in the Journal of Leukocyte Biology(http://www.jleukbio.org) suggests that two frequent mutations in an immune system gene called TLR1 are responsible for cellular changes that ultimately make us less likely to resist the disease. Read More
UTHealth researchers find diabetics at higher risk of tuberculosis infection
People with diabetes have a three to five times higher risk of contracting tuberculosis (TB) than non-diabetics, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).
Results of the study, which included 233 patients with TB who live in Texas and Mexico along the border, are published in the May issue of the Bulletin of the World Health Organization. It was funded by the National Institutes of Health.
“With the increase in diabetes patients in TB-endemic areas, our findings highlight the re-emerging impact of diabetes mellitus, known as type 2, on TB control in regions of the world where both diseases are prevalent,” said Blanca Restrepo Ph.D., lead investigator and associate professor of epidemiology at The University of Texas School of Public Health Brownsville Regional Campus, a part of UTHealth. “There is a need to focus on identifying the opportunities to prevent TB in diabetes patients.” Read More
Mortality and associated risk factors in a cohort of tuberculosis patients treated under DOTs programme in Addis Ababa, Ethiopia.
Background:
Tuberculosis (TB) is the leading cause of mortality among infectious diseases worldwide. Ninty five percent of TB cases and 98% of deaths due to TB occur in developing countries. Globally, the mortality rate has declined with the introduction of effective anti TB chemotherapy. Nevertheless, some patients with active TB still die while on treatment for their disease. In Ethiopia, little is known on survival and risk factors for mortality among a cohort of TB patients. The objective of the study is to determine the magnitude and identify risk factors associated with time to death among TB patients treated under DOTS programme in Addis Ababa, Ethiopia. Read More
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The Treatment of Tuberculosis: Guidelines :: Amazon The World Health Organization's Stop TB Department has prepared this fourth edition of Treatment of Tuberculosis: Guidelines , adhering full |
A new experimental diagnostic test able to quickly distinguish infection from tuberculosis disease
The results of a preliminary study, the work of a research team of the Catholic University, National Institute of Infectious Diseases “L. Spallanzani” and the University of Sassari published on the international journal PLoS One
A potential new experimental diagnostic test able to quickly distinguish individuals with active tuberculosis (TB) from those with latent TB infection has been developed. If the preliminary results of the study will be confirmed in a larger population sample, the new diagnostic system could allow more effective strategies to control the spread of the re-emerging pathology. Read More
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Mycobacterium Bovis Infection in Animals and Humans :: Amazon Written by tuberculosis specialists from around the world, Mycobacterium Bovis Infection in Animals and Humans, Second Edition remains the m |
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Handbook of Tuberculosis: Immunology and Cell Biology :: Amazon Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people |
Effectiveness of the Standard WHO Recommended Retreatment Regimen (Category II) for Tuberculosis in Kampala, Uganda: A Prospective Cohort Study
Prospective evaluation of the effectiveness of the WHO-recommended standardized retreatment regimen for tuberculosis by Edward Jones-López and colleagues reveals an unacceptable proportion of unsuccessful outcomes.
The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module
Author Summary
Tuberculosis (TB), an infectious disease caused by the bacillus Mycobacterium tuberculosis, burdens large swaths of the world population. Treatment of active TB typically requires administration of an antibiotic cocktail over several months that includes the drug ethambutol. This front line compound inhibits a set of arabinosyltransferase enzymes, called EmbA, EmbB and EmbC, which are critical for the synthesis of arabinan, a vital polysaccharide in the pathogen’s unique cell envelope. Read More
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Mycobacterium Tuberculosis Protocols (Methods in Molecular Medicine) :: Amazon Leading investigators with extensive practical knowledge and experience describe their best methods for studying the tuberculosis pathogen. |
The BCG World Atlas: a world first in the fight against tuberculosis
McGill, RI MUHC researchers launch free online atlas of TB vaccination policies from around the world
Tuberculosis (TB) continues to pose a major global health threat. Someone in the world is newly infected with TB bacteria every second. Every year, more than 9 million people develop active TB and it claims about 2 million lives. In Canada, the overall incidence of TB has declined, but rates remain high among immigrants from endemic countries and among Aboriginal populations. Currently, Nunavut is facing the largest TB outbreak in the territory’s 10- year history. Read More
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Clinical Tuberculosis (A Hodder Arnold Publication) :: Amazon Clinical Tuberculosis remains an indispensable resource for respiratory physicians, infectious disease specialists, public health workers an |
Treatments for recurring TB infection failing the developing world, study finds
The standard approach to re-treating tuberculosis (TB) in low and middle income settings is failing, according to research funded by the Wellcome Trust. In a study published today in the open access journal PLoS Medicine, researchers call for improved access to rapid diagnostics for drug resistant TB, second-line TB treatment and antiretroviral HIV therapy. Read More
Human Macrophage Responses to Clinical Isolates from the Mycobacterium tuberculosis Complex Discriminate between Ancient and Modern Lineages
Author Summary
Mycobacterium tuberculosis is a long-standing human pathogen spread by aerosol transmission between individuals interacting in close social groups. It can be anticipated that the evolution of M. tuberculosis will parallel the evolution of human societies, and the phylogeny as determined by whole genome sequencing of clinical isolates is indeed consistent with emergence of the pathogen with modern humans in Africa and its subsequent dissemination along routes of human migration and trade. The present study was designed to test the hypothesis that the genetic diversity of M. tuberculosis isolates would be reflected in a corresponding diversity in their biological properties. Read More
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