Background:
The absence of antibodies specific for the 19 kDa C-terminal domain of merozoite surface protein 1 (MSP119) has been associated with high-density malaria parasitaemia in African populations. The hypothesis that a high prevalence and/or level of anti-MSP119 antibodies that may inhibit erythrocyte invasion would be present in apparently healthy individuals who harbour a sub-microscopic malaria infection was tested in this study. Read More
Fine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum Merozoite Surface Protein 1 types in individuals in Nigeria with sub-microscopic infection
The quest for universal access to effective malaria treatment: how can the AMFm contribute?
Access to quality assured artemisinin-based combination therapy (ACT) has remained very low in most malaria endemic countries. A number of reasons, including unaffordable prices, have contributed to the low accessibility to these life-saving medicines. The Affordable Medicines Facility-Malaria (AMFm) is a mechanism to increase access to quality assured ACT. Read More
Profound and Sustained Reduction in Chlamydia trachomatis in The Gambia: A Five-Year Longitudinal Study of Trachoma Endemic Communities
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Author Summary
Trachoma is the most common infectious cause of blindness worldwide. Mass antibiotic treatment with azithromycin is used to control ocular Chlamydia trachomatis infection. There is uncertainty over how frequently and for how long treatment is needed, particularly in low prevalence settings. Read More
2nd International External Quality Control Assessment for the Molecular Diagnosis of Dengue Infections
Author Summary
Dengue viruses (DENV) are the most widespread arthropod-borne viruses which have shown an unexpected geographic expansion, as well as an increase in the number and severity of outbreaks in the last decades. In this context, the accurate diagnosis and reliable surveillance of dengue infections are essential. Read More
Lack of antiepileptic drugs hurts awareness, treatment efforts in Zambia
Hurdles must be overcome for ‘Out of the Shadows’ campaign
EAST LANSING, Mich. — Despite an international effort to raise awareness about epilepsy in resource-poor nations, a recently published study found nearly 50 percent of pharmacies in Zambia do not carry antiepileptic drugs, seriously hampering efforts to tackle one of the most cost-effective chronic conditions to treat. Read More
Biting behaviour of Simulium damnosum complex and Onchocerca volvulus infection along the Osun River, Southwest Nigeria
Background:
Studies on biting behaviours and infectivity status of insect vectors are pre-requisites in understanding the epidemiology of the vector- borne diseases and planning effective control measures. A longitudinal study was carried out to investigate the transmission index of Simulium damnosum complex species along Osun River, South Western Nigeria. Adult flies were collected on human attractants from 07:00 to 18:00 hours for two consecutive days from February 2008 to June 2009 at three communities: Osun Eleja, Osun Ogbere and Osun Budepo. The infectivity rate was determined by dissection and Polymerase Chain Reaction amplification (PCR) of 0-150 genes of Onchocerca parasite using the pool screening technique. Read More
[Reflection and Reaction] Maximising the public health benefit of antimalarials
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Artemisinin combination therapies (ACTs) are integral to current malaria treatment strategies. They effect rapid and complete clearance of multidrug-resistant strains of Plasmodium spp, decrease the transmission potential of the parasite, and limit the emergence of de novo resistance.
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Re: Review article titled, “Rifamycins – Obstacles and opportunities” by Paul A. Aristoff, George A. Garcia, Paul D. Kirchhoff, H.D. Hollis Showalter. Tuberculosis 2010; 90(2):94–118
We would like to make the following comments regarding rifalazil, one of the rifamycin analogs that were included in the review manuscript. Contrary to what was stated in the review, rifalazil’s clinical development is still ongoing and was not halted because of major side effects seen in humans; however, in the past the focus of the clinical program was shifted from the treatment of tuberculosis to other indications. Read More
Activity of β-lapachone derivatives against rifampicin-susceptible and -resistant strains of Mycobacterium tuberculosis
Summary: The increase of incidence of tuberculosis (TB) with resistant strains and HIV co-infection has reinforced the necessity of developing new drugs for its treatment. The reaction of naphthoquinones with aromatic or aliphatic aldehydes in the presence of ammonium acetate led to the synthesis of the three β-lapachone derivatives (naphthoimidazoles) that were tested in this study. Phenazines were prepared by the reaction of the respective naphtoquinone with o-phenylenediamine in acetic acid under reflux. Read More
Disease Outbreaks- Avian influenza – situation in Indonesia – updateThe Indonesian IHR National Focal Point of the Ministry of Health has notified WHO of a new case of human infection with avian influenza A(H5N1) virus. […]
- Avian influenza – situation in Egypt – updateThe Ministry of Health and Population of Egypt has notified WHO of a new case of human infection with avian influenza A (H5N1) virus. […]
- Avian influenza – situation in Cambodia – updateThe Ministry of Health (MoH) of the Kingdom of Cambodia has announced a confirmed case of human infection with avian influenza A (H5N1) virus. […]
- Lassa fever in NigeriaAt the beginning of 2012, WHO was notified by the Federal Ministry of Health in Nigeria of an outbreak of Lassa fever. As of March 22, 2012, 623 suspected cases, including 70 deaths have been recorded from 19 of the 36 States since the beginning of the year. Laboratory analysis undertaken at the Irrua Specialist Teaching Hospital, Irrua Edo State has confirm […]
- Avian influenza – situation in Egypt – updateThe Ministry of Health and Population of Egypt has notified WHO of two new cases of human infection with avian influenza A (H5N1) virus. […]
- Avian influenza – situation in Indonesia – update
Cheap Calls to Kenya
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Mendeley Related Research
