Primary Human Mammary Epithelial Cells Endocytose HIV-1 and Facilitate Viral Infection of CD4+ T Lymphocytes [Pathogenesis and Immunity]

The contribution of mammary epithelial cells (MEC) to human immunodeficiency virus type 1 (HIV-1) in breast milk remains largely unknown. While breast milk contains CD4+ cells throughout the breast-feeding period, it is not known whether MEC directly support HIV-1 infection or facilitate infection of CD4+ cells in the breast compartment. Read More

PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial.

PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial.

Lancet. 2010 Sep 17;

Authors: McCormack S, Ramjee G, Kamali A, Rees H, Crook AM, Gafos M, Jentsch U, Pool R, Chisembele M, Kapiga S, Mutemwa R, Vallely A, Palanee T, Sookrajh Y, Lacey CJ, Darbyshire J, Grosskurth H, Profy A, Nunn A, Hayes R, Weber J

BACKGROUND: Innovative prevention strategies for HIV-1 transmission are urgently needed. PRO2000 vaginal gel was efficacious against HIV-1 transmission in studies in macaques; we aimed to assess efficacy and safety of 2% and 0·5% PRO2000 gels against vaginal HIV-1 transmission in women in sub-Saharan Africa. Read More

The Effect of Community-Based Support Services on Clinical Efficacy and Health-Related Quality of Life in HIV/AIDS Patients in Resource-Limited Settings in Sub-Saharan Africa.

The Effect of Community-Based Support Services on Clinical Efficacy and Health-Related Quality of Life in HIV/AIDS Patients in Resource-Limited Settings in Sub-Saharan Africa.

AIDS Patient Care STDS. 2010 Aug 28;

Authors: Kabore I, Bloem J, Etheredge G, Obiero W, Wanless S, Doykos P, Ntsekhe P, Mtshali N, Afrikaner E, Sayed R, Bostwelelo J, Hani A, Moshabesha T, Kalaka A, Mameja J, Zwane N, Shongwe N, Mtshali P, Mohr B, Smuts A, Tiam A

Abstract Antiretroviral therapy (ART) for HIV/AIDS in developing countries has been rapidly scaled up through directed public and private resources. Data on the efficacy of ART in developing countries are limited, as are operational research studies to determine the effect of selected nonmedical supportive care services on health outcomes in patients receiving ART. Read More

The health education nurse faced with an African HIV-infected patient

[The health education nurse faced with an African HIV-infected patient]

Soins. 2010 Jul-Aug;(747):31-2

Authors: Tocheport P

The health education nurse faced with an African HIV-infected patient. Disease and death are represented in a completely different manner in Sub-Saharan Africa than in the West. The role of the health education nurse working with African HIV-infected patients requires a socio-ethnological understanding of this cultural context in order to provide a global, personalised and adapted treatment.

PMID: 20799487 [PubMed - in process]

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Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

Int J Dermatol. 2010 Jan;49(1):83-6

Authors: Navarini AA, Stoeckle M, Navarini S, Mossdorf E, Jullu BS, Mchomvu R, Mbata M, Kibatala P, Tanner M, Hatz C, Schmid-Grendelmeier P

Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.

PMID: 20465620 [PubMed - indexed for MEDLINE]

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Modeling contextual determinants of HIV/AIDS prevalence in South Africa to inform policy.

Modeling contextual determinants of HIV/AIDS prevalence in South Africa to inform policy.

Afr J Reprod Health. 2009 Sep;13(3):53-69

Authors: Bouare O

There is a voluminous literature on HIV/AIDS and South Africa. However, no study focuses on the modeling of contextual factors concerning HIV/AIDS prevalence in South Africa. In this paper, two models of contextual behavioral risk factors of HIV/AIDS prevalence were developed so that policy makers can be alerted to the key variables in order to help curb the spread of the disease. Read More

Liberia: Roch Conducts HIV/Aids Awareness for Over 334 Young People in Maryland

A group of trained coaches and leaders under the umbrella Restoring Our Children’s Hope (ROCH) has conducted a one day sensitization and awareness campaign on HIV/AIDS for over 334 young people in Gbamlesiewlor. Gbamlesiewlor is one of the biggest communities in Hoffman Station Township near Harper, Maryland County.
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KENYA: Government changes tack on HIV prevention, treatment for drug users

NAIROBI, 24 August 2010 (PLUSNEWS) – Intravenous drug users have been largely ignored by the government’s HIV programmes on the basis that drug-taking is illegal, but a new policy is being drafted with the aim of reducing HIV transmission among this high-risk group.
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The social determinants of HIV serostatus in sub-Saharan Africa: an inverse relationship between poverty and HIV?

The social determinants of HIV serostatus in sub-Saharan Africa: an inverse relationship between poverty and HIV?

Public Health Rep. 2010 Jul-Aug;125 Suppl 4:16-24

Authors: Fox AM

Contrary to theories that poverty acts as an underlying driver of human immunodeficiency virus (HIV) infection in sub-Saharan Africa (SSA), an increasing body of evidence at the national and individual levels indicates that wealthier countries, and wealthier individuals within countries, are at heightened risk for HIV.

This article reviews the literature on what has increasingly become known as the positive-wealth gradient in HIV infection in SSA, or the counterintuitive finding that the poor do not have higher rates of HIV. This article also discusses the programmatic and theoretical implications of the positive HIV-wealth gradient for traditional behavioral interventions and the social determinants of health literature, and concludes by proposing that economic and social policies be leveraged as structural interventions to prevent HIV in SSA.

PMID: 20629252 [PubMed - indexed for MEDLINE]

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BURUNDI: HIV-positive people struggling for treatment of opportunistic infections

BUJUMBURA, 11 August 2010 (PLUSNEWS) – Thousands of Burundians living with HIV are failing to obtain drugs to treat opportunistic infections since a system to provide them with free medical care has come to an end.
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A cure for HIV could be all in the ‘mix’

Current HIV treatments do not eradicate HIV from host cells but rather inhibit virus replication and delay the onset of AIDS. However, a new research published in BioMed Central’s open access journal, AIDS Research & Therapy describes an innovative approach to eliminate HIV in host by targeted killing of only HIV infected cells. This approach if successful could lead into an anti-HIV therapy that will eradicate the virus. Read More

Short Communication: Severe Symptomatic Hyperlactatemia Among HIV Type 1-Infected Adults on Antiretroviral Therapy in Côte d’Ivoire.

Short Communication: Severe Symptomatic Hyperlactatemia Among HIV Type 1-Infected Adults on Antiretroviral Therapy in Côte d’Ivoire.

AIDS Res Hum Retroviruses. 2010 Aug 14;

Authors: Minga A, Lewden C, Dohoun L, Abo Y, Emieme A, Coulibaly A, Salamon R, Eholié S, Anglaret X, Danel C

Abstract Stavudine is no longer recommended for use in first-line antiretroviral therapy (ART), but it remains in high demand worldwide because it is affordable. We report the clinical presentation and incidence of severe hyperlactatemia (SL) in HIV-infected adults who initiated ART between April 2005 and May 2009 in Côte d’Ivoire, West Africa. In a prospective cohort study at the HIV care center affiliated with the National Centre for Blood Transfusion, we used standardized forms to record baseline and follow-up data. We measured serum lactate levels for all adults on ART who showed signs of hyperlactatemia. SL was defined as serum lactate >2.5 mmol/liter. Overall, 806 adults initiated ART. Among the 591 patients (73%) on stavudine-containing regimens, 394 were women (67%); the median pre-ART CD4 count was 150 /mm(3) and the median body mass index was 20.9 kg/m(2). Read More

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