Background:
The role of interferon-gamma release assay (IGRA) in monitoring responses to anti-tuberculosis (TB) treatment is not clear. We evaluated the results of the QuantiFERON-TB Gold In-tube (QFT-GIT) assay over time during the anti-TB treatment of adults with no underlying disease. Read More
Serial interferon-gamma release assays during treatment of active tuberculosis in young adults
Scientists assess new vaccines to improve health of African children

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Respiratory infections and diarrhoeal diseases kill approximately four million children each year, with most deaths occurring in developing countries. New vaccines for Streptococcus pneumoniae, a bacterium that causes pneumonia, and rotavirus, the most common cause of severe diarrhoea, have proved successful in preventing the development of the diseases in clinical trials, but have yet to be used routinely in many parts of Africa. Read More
Lack of antiepileptic drugs hurts awareness, treatment efforts in Zambia
Hurdles must be overcome for ‘Out of the Shadows’ campaign
EAST LANSING, Mich. — Despite an international effort to raise awareness about epilepsy in resource-poor nations, a recently published study found nearly 50 percent of pharmacies in Zambia do not carry antiepileptic drugs, seriously hampering efforts to tackle one of the most cost-effective chronic conditions to treat. Read More
Researchers sequence genome of mosquito that spreads West Nile virus

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UC Riverside researchers spearheaded the multiyear project that could result in novel strategies to fight West Nile and other Culex-transmitted diseases
RIVERSIDE, Calif. – Last year, 720 people in the United States became infected with West Nile virus, a potentially serious illness that is spread through the bite of a mosquito – theCulex mosquito – that has first fed on infected birds. Such mosquitoes have the virus eventually located in their salivary glands and transmit the disease to humans and animals when they bite to draw blood. Read More
In-country OB/GYN training programs contributed to retention of doctors in Ghana, U-M study shows
Residents stayed in Ghana because they felt they could make it there economically, were supported by educational opportunities
ANN ARBOR, Mich. — Ghanaian Obstetrics and Gynecology residents say in-country training programs contributed to their decision to remain in their home country to practice medicine, new University of Michigan research shows.
The retention of trained health care providers in developing countries is a key component to improving health and achieving the United Nations’ Millennium Development Goals, which aim to decrease maternal and child mortality. But the migration of health workers from developing to developed countries has resulted in a health care workforce crisis that continues to threaten progress in global health. Read More
Tick-Borne Rickettsioses, Neglected Emerging Diseases in Rural Senegal
Author Summary
Spotted fever rickettsioses are endemic diseases known since the beginning of the 21st century. They may be severe, like Rocky Mountain Spotted fever in the Americas, and are always transmitted by the tick bite. In Africa, little is known about the prevalence of these diseases; most available data is from the travelers who felt ill after coming back to Europe and USA. Read More
Rv1985c, a promising novel antigen for diagnosis of tuberculosis infection from BCG vaccinated controls

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Background:
Antigens encoded in the region of deletions (RD) of Mycobacterium tuberculosis constitute a potential source of specific antigens for immunodiagnosis and vaccine development. In the present study, recombinant protein Rv1985c from RD2 was cloned, expressed, purified, immunologically characterized and investigated for its potentially diagnostic value for tuberculosis infection among BCG vaccinated individuals. Read More
Aeras and Crucell announce Phase II clinical trial start in Kenya
Study to test new tuberculosis vaccine in infants
Leiden, The Netherlands / Rockville, MD, USA (September 22, 2010) – Dutch biopharmaceutical company Crucell N.V. (Euronext, Nasdaq: CRXL; Swiss Exchange: CRX) and the Aeras Global TB Vaccine Foundation today announced the start of a Phase II clinical trial in infants of the jointly developed tuberculosis (TB) vaccine candidate, AERAS-402/Crucell Ad35. Read More

