Serial interferon-gamma release assays during treatment of active tuberculosis in young adults

Background:
The role of interferon-gamma release assay (IGRA) in monitoring responses to anti-tuberculosis (TB) treatment is not clear. We evaluated the results of the QuantiFERON-TB Gold In-tube (QFT-GIT) assay over time during the anti-TB treatment of adults with no underlying disease. Read More

Tuberculosis transmission to young children in a South African community: modeling household and community infection risks.

Tuberculosis transmission to young children in a South African community: modeling household and community infection risks.

Clin Infect Dis. 2010 Aug 15;51(4):401-8

Authors: Wood R, Johnstone-Robertson S, Uys P, Hargrove J, Middelkoop K, Lawn SD, Bekker LG

BACKGROUND: Tuberculosis transmission is determined by contact between infectious and susceptible individuals. A recent study reported a 4% annual risk of child tuberculosis infection in a southern African township. A model was used to explore the interactions between prevalence of adult tuberculosis infection, adult-to-child contacts, and household ventilation, which could result in such a high annual risk of tuberculosis infection. METHODS: Number of residents per household and tuberculosis incidence were derived from a household census and community tuberculosis registers. Read More

Spatial distribution and cluster analysis of sexual risk behaviors reported by young men in Kisumu, Kenya.

Spatial distribution and cluster analysis of sexual risk behaviors reported by young men in Kisumu, Kenya.

Int J Health Geogr. 2010;9:24

Authors: Westercamp N, Moses S, Agot K, Ndinya-Achola JO, Parker C, Amolloh KO, Bailey RC

BACKGROUND: The well-established connection between HIV risk behavior and place of residence points to the importance of geographic clustering in the potential transmission of HIV and other sexually transmitted infections (STI). Read More

Imaging-based disease pattern in a consecutive series of cranial CTs and MRIs in a rural and an urban Tanzanian hospital: a comparative, retrospective, neuroradiological analysis.

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Imaging-based disease pattern in a consecutive series of cranial CTs and MRIs in a rural and an urban Tanzanian hospital: a comparative, retrospective, neuroradiological analysis.

Wien Klin Wochenschr. 2010 Oct 8;

Authors: Maier D, Doppler M, Gasser A, Zellner H, Dharsee J, Schmutzhard E, Winkler AS

The prevalence of neurological diseases and cranial pathologies in sub-Saharan Africa remains a very little investigated field. This study aims at providing an imaging-based overview of cranial pathologies in two Tanzanian hospitals and at identifying possible differences in the spectrum of diseases between rural and urban African populations. At rural Haydom Lutheran Hospital (Manyara region) the data of 726 patients were included in a retrospective survey. Read More

Scientists assess new vaccines to improve health of African children

Streptococcus pneumoniae in spinal fluid. FA s...
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Respiratory infections and diarrhoeal diseases kill approximately four million children each year, with most deaths occurring in developing countries. New vaccines for Streptococcus pneumoniae, a bacterium that causes pneumonia, and rotavirus, the most common cause of severe diarrhoea, have proved successful in preventing the development of the diseases in clinical trials, but have yet to be used routinely in many parts of Africa. Read More

Lack of antiepileptic drugs hurts awareness, treatment efforts in Zambia

Hurdles must be overcome for ‘Out of the Shadows’ campaign

EAST LANSING, Mich. — Despite an international effort to raise awareness about epilepsy in resource-poor nations, a recently published study found nearly 50 percent of pharmacies in Zambia do not carry antiepileptic drugs, seriously hampering efforts to tackle one of the most cost-effective chronic conditions to treat. Read More

Researchers sequence genome of mosquito that spreads West Nile virus

Culex mosquitos (Culex quinquefasciatus shown)...
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UC Riverside researchers spearheaded the multiyear project that could result in novel strategies to fight West Nile and other Culex-transmitted diseases

RIVERSIDE, Calif. – Last year, 720 people in the United States became infected with West Nile virus, a potentially serious illness that is spread through the bite of a mosquito – theCulex mosquito – that has first fed on infected birds. Such mosquitoes have the virus eventually located in their salivary glands and transmit the disease to humans and animals when they bite to draw blood. Read More

In-country OB/GYN training programs contributed to retention of doctors in Ghana, U-M study shows

Residents stayed in Ghana because they felt they could make it there economically, were supported by educational opportunities

ANN ARBOR, Mich. — Ghanaian Obstetrics and Gynecology residents say in-country training programs contributed to their decision to remain in their home country to practice medicine, new University of Michigan research shows.

The retention of trained health care providers in developing countries is a key component to improving health and achieving the United Nations’ Millennium Development Goals, which aim to decrease maternal and child mortality. But the migration of health workers from developing to developed countries has resulted in a health care workforce crisis that continues to threaten progress in global health. Read More

Tick-Borne Rickettsioses, Neglected Emerging Diseases in Rural Senegal

Author Summary

Spotted fever rickettsioses are endemic diseases known since the beginning of the 21st century. They may be severe, like Rocky Mountain Spotted fever in the Americas, and are always transmitted by the tick bite. In Africa, little is known about the prevalence of these diseases; most available data is from the travelers who felt ill after coming back to Europe and USA. Read More

Rv1985c, a promising novel antigen for diagnosis of tuberculosis infection from BCG vaccinated controls

Mycobacterium tuberculosis'' (stained red) in ...
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Background:
Antigens encoded in the region of deletions (RD) of Mycobacterium tuberculosis constitute a potential source of specific antigens for immunodiagnosis and vaccine development. In the present study, recombinant protein Rv1985c from RD2 was cloned, expressed, purified, immunologically characterized and investigated for its potentially diagnostic value for tuberculosis infection among BCG vaccinated individuals. Read More

Infection by discordant strains of HIV-1 markedly enhances the neutralizing antibody response against heterologous virus.

Infection by discordant strains of HIV-1 markedly enhances the neutralizing antibody response against heterologous virus.

J Virol. 2010 Sep;84(18):9415-26

Authors: Powell RL, Kinge T, Nyambi PN

High-risk cohorts in East Africa and the United States show rates of dual HIV-1 infection–the concomitant or sequential infection by two HIV-1 strains–of 50% to 100% of those of primary infection, and our normal-risk HIV-positive cohort in Cameroon exhibits a rate of dual infection of 11% per year, signifying that these infections are not exceptional. Little is known regarding the effect of dual infections on host immunity, despite the fact that they provide unique opportunities to investigate how the immune response is affected when challenged with diverse HIV-1 antigens. Read More

Aeras and Crucell announce Phase II clinical trial start in Kenya

Study to test new tuberculosis vaccine in infants

Leiden, The Netherlands / Rockville, MD, USA (September 22, 2010) – Dutch biopharmaceutical company Crucell N.V. (Euronext, Nasdaq: CRXL; Swiss Exchange: CRX) and the Aeras Global TB Vaccine Foundation today announced the start of a Phase II clinical trial in infants of the jointly developed tuberculosis (TB) vaccine candidate, AERAS-402/Crucell Ad35. Read More

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